New findings in neuroscience give hope to brain injured patients

A recent study at the University of Western in Ontario, Canada is suggested a second look at coma patients in a vegetative state may be required before “pulling the plug”.

Following an experiment with MRI technology, Professor Adrian Owen and Postdoctoral Fellow Lorina Naci have determined that a man in a coma – the result of a serious car accident – is aware of his surroundings and his identity. This breakthrough finding challenges many of the assumptions about “vegetative” patients, and gives hope to their families.

Dr. Owen, a Canada Research Chair, is behind the groundbreaking studies that examine patients under the medical sentence “vegetative state”. He suggests that these patients are simply incapable of “generating” — which simply means they don’t have the ability to communicate.  However, he says these patients still have the intention to communicate, making them a conscious human being with functioning capacities.

MRI images prove Dr. Owens hypothesis to be true.  Using a comparison chart of a healthy human brain and that of a vegetative patient he provides a visual aid that shows the specific areas of the brain that signal a “yes” or “no” answer to a set of questions.  The questions used have specific answers routed in the patient’s reality to test if the brain is of sound mind.

Dr.Owen is not the only doctor leading the research in neuroscience. Jill Bolte Taylor originally entered the field of brain science as a result of her schizophrenic brother.  She became a highly acclaimed scientist at Harvard University. On Dec. 10, 1996 a blood vessel exploded in the left half of her brain. From that day forward Jill could no longer walk, talk becoming an infant in a woman’s body.

In her book, My Stroke of Insight: A Brain Scientist’s Personal Journey, Jill shares her personal story. (See her TED talk) Remarkably, during her stroke she was able to analyze and understand her experience.  She would agree with Dr.Owen.  After she recover from her vegetative state which lasted five years, she described the awareness that her mom was with her in a room. She also talks about the desire to respond and interact with others.

 

 

 

 

Grow a replacement human heart using pigs and stem cells

They say bacon is not good for the heart. In Heidelberg, Germany, that is changing. Our porky little friends are being used to produce scaffolds for refreshed hearts infused with human stem cells. This results in transplantable hearts for those that can’t wait for donor human hearts.

The first step in the process of creating a pig heart for transplant into a human from to strip the pig’s heart of pig heart cells.
Then the resulting scaffold is refreshed with stem cells from a human. The result: a pig heart transformed with human cells.

What does this mean for humans?

Well, in terms of heart transplants we will have the ability to treat everyone who needs one.  Right now there is a shortage of human heart donors.  There are thousands of people waiting to receive a transplanted healthy heart from an unfortunate accident victim.

The new pig-powered procedure is experimental. And it may be decades before it can be performed to help humans. Controversy around stem cells is not helping matters. Still, these advancements may one day lead to the replacement of organs such as, lungs, livers and kidneys.

Learn more in this video: A New Heart Grown from Stem Cells

 

Why men who marry young wives live longer

If you are a man and you want to live longer the answer, it seems, is simple.  A recent study by German experts revealed that men who marry younger women enhance their chances of longevity. So, if you are a man go ahead and shack up with a woman 15-17 years less your senior.  It my mean a longer lifespan and healthier future for you!

The analysis was conducted by a research group at Max Planck Institute for Demographic Research in Rostock, Germany. The researchers looked at the deaths of the entire population of Denmark between 1990 and 2005. Danish men who marry women much younger than them live longer.

Old men attract younger women.

Why do men that marry younger women live longer?

One hypothesis that explains the increased rate of longevity is natural selection. It is possible that younger women choose healthier, better maintained older men as their marriage mates. Therefore, it is these types of men who are naturally taking care of their health and as such have a better chance of living longer.

A second idea presents the notion that many men with considerably younger wives are rich. Because of their financial means, these men enjoy a more comfortable lifestyle than average men, i.e. they have no worries about money, better access to regular medical checks, health cures, leisure, etc. All these factors contribute to a long life span.

Another theory, suggested by Sven Drefahl of the Max Planck Institute, points to the fact that a younger woman will care for a man better and therefore he will live longer. A younger spouse may also have a beneficial psychological effect on the older partner and provide them with better care in old age.

What about women?

The funny thing is the same results bode useless to our female friends.  Women who marry men older or younger by seven to nine years increase their chances of dying by 20 percent. If the age difference is close to 15 to 17 years, the figure goes up to 30 percent. Increased stress has been speculated as the cause of early death for these women.

The good news?

Women have a higher life expectancy than men. The average life expectancy for a women is 82 compared to 78 for a man.  Therefore, in the end it may just even out for us.

So, if there is a significant age difference between you are your honey, no need to fear, just keep on loving!

A cure for blind mice and possibly humans

The childhood song Three Blind Mice, which recounts the tale of three blind mice getting into trouble with the farmer’s wife may be obsolete in the near future.  While researchers continue to work on aids for the blind, a team at UCL has found the answer.   Three blind mice, no more!

Researchers have found a cure for blindness in mice.

A recent paper in the journal Natural Biochemistry documents the successful implantation of photoreceptors into the receptors of blind mice, restoring their vision. Thus, blind mice may become history very soon, and the same thing goes for us humans!

HOW DID THEY DO IT?

A team of researchers at UCL Institute of Ophthalmology and Moorfields Eye Hospital, led by Professor Robin Ali, obtained the photoreceptors from a “synthetic retina” grown in a lab dish.  They used a Japanese technqiue that mimics the natural process of retinal growth in embryos.  Then they injected 200,000 of the cultured cells into living mouse retinas. Miraculously it only took six weeks for the necessary neural connections to form and to communicate visual data to the brain

The next step is to start trials with human cells that will be eventually used in human clinical trials.  At this point, we are still years away.

WHAT ABOUT NOW…?

Although there is still a great debate and a lot of regulations around clinical trials involving stem cells, therapies that target retinal pigment epithelium (RPE) are completely legal.  The reason for the allowance – RPE trials involved cells that are terminally differentiated, accessible, and form no synaptic connections.

Dr. Schwartz successfully implanted RPE cells derived from embryonic stem cells into the retina. In two distinct cases; one patient suffering from macular degeneration and the other from Stargardt’s, the therapies proved a small success.  Both patients reported moderate visual improvement.

EYE TECHNOLOGY

Argus II Optical Implant

A pair of telescopic contact lenses or the Argus II optical implant (for those suffering from retinitis pigmentosa)  use technology to aim to circumvent the problem areas. The Argus II implant has been commercially available in Europe since 2011 (for a hefty $100,000) and was approved by the FDA here in the US earlier this year.

Once again technology and medicine have come together to un-write what we have written as an impossible feat.  It may only be a few more years until we see the demise of glasses and a cure for the blind.  If you want to learn more, check out the original article at singularity hub.

Nasal spray makes snake bites survivable

A new nasal spray may give snake bite victims at shot at survival.

As many as 125,000 people die each year from from venomous snake bites. The challenge? Getting to a hospital in time to get a dose of anti-venom. Most victims die on the way.

Drugs used to treat snakebites aren’t easy to use in the wild. So researchers developed a nasal spray to deliver anti-venom drugs (anticholinesterase agents such as neostigmine.) They have been used for decades on snake bite victims, but the challenge is they have to be administered with a needle.

In April 2013, researchers from the California Academy of Sciences and the University of California, San Francisco tested delivery of the life saving medicine via nasal spray. In India a doctor has since successfully used the spray to reverse facial paralysis in a patient who had been bitten by a krait, a common venomous snake found in Indian and south Asian jungles. One bite from a krait has enough venom to kill two grown men.

The patient recovered from the facial paralysis in half an hour, and was back on their feet within two weeks.

Nasal spray makes snake bites survivable